Examining the Relationship Between Subjective and Reinforcing Effects of Stimulant Drugs: Implications for Human Laboratory and Clinical Trial Research
|Sunday, May 25, 2014
|9:00 AM–9:50 AM
|W375e (McCormick Place Convention Center)
|Area: BPH; Domain: Basic Research
|Instruction Level: Basic
|CE Instructor: William Stoops, Ph.D.
|Chair: Paul L. Soto (Texas Tech University)
|WILLIAM STOOPS (University of Kentucky College of Medicine)
|Dr. William Walton Stoops, an associate professor in the Departments of Behavioral Science and Psychology at the University of Kentucky, earned his bachelor's degree in psychology from Davidson College in Davidson, NC, and his master's degree and Ph.D. in psychology from the University of Kentucky. His research utilizes sophisticated human laboratory methods like self-administration and drug-discrimination to examine behavioral and pharmacological factors contributing to drug-use disorders. He has written more than 75 manuscripts and book chapters as author or co-author. His recent work has centered specifically on evaluating laboratory models of pharmacological and behavioral interventions for stimulant-use disorders and determining the neuropharmacological effects of stimulants and opioids. This research has resulted in numerous awards from professional societies including the 2013 Joseph Cochin Young Investigator Award from the College on Problems of Drug Dependence, the 2006 Outstanding Dissertation Award and the 2008 Wyeth Young Psychopharmacologist Award from Division 28 (Psychopharmacology and Substance Abuse) of the American Psychological Association. Dr. Stoops is a Fellow of APA and the Midwestern Psychological Association and will serve as president of APA Division 28 in 2015.
Subject-rated measures and drug self-administration represent two of the most commonly used methods of assessing the behavioral effects of drugs in the human laboratory. Although the results from these methods are often consistent, dissociations between subjective and self-administration data have been observed. This presentation will first introduce basic human behavioral pharmacology methods for measuring subjective and reinforcing effects of drugs, focusing on representative data from commonly abused stimulants. Second, correlational and regression analyses that examined the relationships between subjective and reinforcing drug effects will be presented to demonstrate which subjective measures best predict stimulant self-administration. Third, examples of divergence between subjective and reinforcing drug effects will be explored to show how these measures provide different and complementary information about stimulant drug effects. Potential mechanisms underlying this divergence also will be considered. Finally, the implications of these outcomes as they relate to future human laboratory research and intervention development for managing drug-use disorders will be reviewed.
Psychologists, behavior analysts, graduate students, and anyone interested in methods of assessing the behavioral effects of drugs in the human laboratory.
|Learning Objectives: At the conclusion of the presentation, participants should be able to: (1) Know how subjective and reinforcing effects of drugs are assessed in human behavioral pharmacology studies; (2) Understand the different information provided by measures of subjective and reinforcing effects; and (3) Understand which human laboratory methods have the best predictive validity for screening putative treatments for drug-use disorders.
|Keyword(s): behavioral pharmacology, reinforcing efforts, stimulant drugs, subjective effects