|New Approaches to the Behavioral Pharmacology of Remembering
|Sunday, May 25, 2014
|10:00 AM–10:50 AM
|W178a (McCormick Place Convention Center)
|Area: BPH; Domain: Basic Research
|BACB CE Offered. CE Instructor: Jonathan W. Pinkston, Ph.D.
|Chair: Jonathan W. Pinkston (University of North Texas)
|Presenting Author: MARK GALIZIO (University of North Carolina Wilmington)
The predictive validity of animal models of memory has been disappointing, suggesting a need for new approaches to development of drug treatments. Many of the traditional procedures derive from the cognitive neuroscience approach and pose interpretive difficulties from a stimulus control perspective. EAB-based techniques (e.g., delayed matching to sample) may not address the complexity of stimulus control necessary for translational significance, but can be adapted to do so. This tutorial will provide a brief overview of procedures used in the behavioral pharmacology of remembering and a consideration of their strengths and weaknesses. It also will provide a more detailed analysis of research using novel procedures that vary the number of stimuli to remember as well as the retention interval. For example, the odor span task can be described as an incrementing nonmatch to sample procedure in which the number of sample stimuli to remember increases on each trial. Early results have shown that NMDA-antagonists, but not other classes of compounds, produce selective impairments on performance in this procedure. Variations of these procedures will be described that develop stimulus control by specific combinations of stimulus properties (what stimulus, when it occurred, and where it was presented), making it possible to study drug effects on "episodic" stimulus control.
|MARK GALIZIO (University of North Carolina Wilmington)
|Dr. Mark Galizio has been a prominent figure in the experimental analysis of behavior for more than 30 years. He has published more than 65 peer-reviewed publications; and he has received numerous extramural grants to fund his research. He is a fellow of Divisions 3, 25, and 28 of the American Psychological Association, past associate editor of The Experimental Analysis of Behavior, and has served as the chair of the National Institutes of Health BRLE (Biobehavioral Regulation, Learning, & Ethology) review panel. Dr. Galizio is a recognized expert in the areas of stimulus control and behavior. This talk will focus on some of his innovative research exploring translational models to identify amnestic effects of pharmacological agents.
|Keyword(s): animal models, memory, olfaction