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Why Private Events Are a Mistake |
Monday, May 30, 2011 |
9:00 AM–9:50 AM |
607 (Convention Center) |
Area: DEV; Domain: Theory |
CE Instructor: William Baum, Ph.D. |
Chair: Hayne W. Reese (West Virginia University) |
WILLIAM M. BAUM (University of California, Davis) |
William M. Baum received his A.B. in psychology from Harvard College in 1961. Originally a biology major, he switched into psychology after taking courses from B. F. Skinner and R. J. Herrnstein in his freshman and sophomore years. He returned to Harvard University for graduate study in 1962, where he was supervised by Herrnstein and received his Ph.D. in 1966. He spent the year 1965-66 at Cambridge University, studying ethology at the Sub-Department of Animal Behavior. From 1966 to 1975, he held appointments as post-doctoral fellow, research associate, and assistant professor at Harvard University. He spent two years at the NIH Laboratory for Brain, Evolution, and Behavior and then accepted an appointment in psychology at University of New Hampshire in 1977. He retired from there in 1999. He currently has an appointment as Associate Researcher at University of California, Davis and lives in San Francisco. His research concerns choice, molar behavior-environment relations, foraging, and behaviorism. He is the author of a book, Understanding Behaviorism: Behavior, Culture, and Evolution. |
Abstract: Private events present a dilemma for behavior analysis. On one hand, their reality seems manifest; everyone thinks, senses, and feels. On the other hand, their privacy is problematic for a science of behavior, because one cannot observe them in another creature. Even if we allow that privacy is accidental-only the result of absence of technology-the problem remains, because private events in another creature can only be inferred and therefore are as hypothetical as any mental construct. We may clarify the problem by examining three examples: waiting, hearing, and pain. From these, we see that the problem arises when one asks what a person is doing at a particular moment. Behavior analysts have sometimes tried to distinguish one momentary activity from another by appealing to private events, a move no better than folk psychology. The solution to the problem appears when we see that the phrase "momentary behavior" is an oxymoron. Behavior is temporally extended by its nature, and asking what a person is doing at a moment is a pseudo-question, akin to asking how many angels can dance on the head of a pin. Extended patterns of behavior produce observable, measurable, results. Applying this insight to the examples of waiting, hearing, and pain, we see how it removes the need to talk about private events at all. |
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Training Staff: Evidence-Based Strategies for Supervisors, Consultants, and Clinicians |
Monday, May 30, 2011 |
10:00 AM–10:50 AM |
Four Seasons 4 (Convention Center) |
Area: PRA; Domain: Applied Behavior Analysis |
CE Instructor: Dennis Reid, Ph.D. |
Chair: Ronnie Detrich (Wing Institute) |
DENNIS H. REID (Carolina Behavior Analysis and Support Center) |
Dennis Reid (Ph.D., Florida State University, 1975) has over 35 years experience as a manager and clinician, and has consulted with human service agencies in the majority of states of the United States as well as Canada and New Zealand. He has published over 130 refereed journal articles focusing on applied behavior analysis and staff training and supervision, and authored or co-authored seven books. In 2007 he was awarded Fellowship status in the Association for Behavior Analysis International and in 2006 received the American Association on Intellectual and Developmental Disabilities Annual Research Award. Denny is the founder and current director of the Carolina Behavior Analysis and Support Center in Morganton, North Carolina. |
Abstract: This presentation will describe evidence-based strategies for training important work skills to human service staff. Initially, a description of a behavior analytic model for staff training will be summarized. Next, ways of effectively applying the model will be provided with a focus on practical considerations faced by supervisors, consultants, and clinicians. Means of making staff training procedures acceptable and well received by staff will also be presented. Common mistakes made in staff training endeavors will likewise be summarized, along with recommendations regarding how to avoid obstacles that impede training effectiveness and acceptability. As a result of attending this presentation, attendees will be able to: (a) describe five steps constituting performance- and competency-based staff training, (b) identify three strategies for making staff training programs highly acceptable to staff trainees, and (c) identify three common obstacles to effective training of staff and strategies for overcoming the obstacles. |
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Garfield Park Preparatory Academy: Strategies to Implement Applied Behavior Analysis in an Urban Public School |
Monday, May 30, 2011 |
10:00 AM–10:50 AM |
Korbel Ballroom 2A (Convention Center) |
Area: TBA; Domain: Applied Behavior Analysis |
CE Instructor: Denise Ross, Ph.D. |
Chair: Jessica Singer-Dudek (Teachers College, Columbia University) |
DENISE E. ROSS (The Chicago School of Professional Psychology) |
Denise Ross is the Principal of Garfield Park Preparatory Academy, a public elementary school affiliated with The Chicago School of Professional Psychology. She is also an Associate Professor in the ABA Department at The Chicago School of Professional Psychology and a former Associate Professor at Columbia University and Florida Atlantic University. Dr. Ross has authored and co-authored multiple peer-reviewed publications on the application of behavior analysis to teaching, including a book titled Verbal Behavior Analysis: Inducing and Expanding New Verbal Capabilities in Children with Language Delays. Dr. Ross is a graduate of Spelman College and Columbia University. |
Abstract: Garfield Park Preparatory Academy (GPPA) is a new elementary school that developed as part of the Department of Applied Behavior Analysis at The Chicago School of Professional Psychology. Currently in its second year, GPPA is located in East Garfield Park, a Chicago community with low rate of employment and graduation. The school's mission is to provide strong academic foundations for students in East Garfield Park, and to provide a quality training site for students at The Chicago School of Professional Psychology. In this presentation, Denise Ross will describe the process of starting a public school designed to apply principles of behavior analysis to schooling. Dr. Ross will also discuss the school's community engagement strategies, barriers and successes to its implementation, academic outcomes in the first year, and the school's future goals. |
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The Case for Private Behavioral Events |
Monday, May 30, 2011 |
10:00 AM–10:50 AM |
607 (Convention Center) |
Area: TPC; Domain: Theory |
CE Instructor: Jay Moore, Ph.D. |
Chair: Sam Leigland (Gonzaga University) |
JAY MOORE (University of Wisconsin, Milwaukee) |
Dr. Moore received his master's degree from Western Michigan University in 1969, where his adviser was Dr. David Lyon. He received his PhD from the University of California--San Diego in 1975, where his adviser was Dr. Edmund Fantino. Dr. Moore is currently on the faculty of the Department of Psychology at the University of Wisconsin--Milwaukee, where he has been since 1977. His principal professional interests are in the experimental analysis of behavior, and the theoretical-philosophical-conceptual analysis of behavior. His recent book is Conceptual Foundations of Radical Behaviorism. He has been a member of ABA since 1977. He served as editor of The Behavior Analyst, as board coordinator for ABAI's Accreditation and Professional Standards Board, and on the ABAI Executive Council, including a term as President of ABAI. |
Abstract: Private behavioral events are an important topic in the theoretical, philosophical, and conceptual orientation of radical behaviorism. This presentation makes the case for private behavioral events by addressing such questions as the following: (a) Of what are we speaking when we speak of private behavioral events? (b) What are two types of private behavioral events? (c) What is the nature and causal status of private behavioral events? (d) Are private behavioral events necessarily related functionally to public behavior? (e) How does the present view of private behavioral events compare with explanations in traditional psychology that appeal to internal, unobservable phenomena? In sum, the presentation argues that we can most effectively understand behavior, and bar the door to mentalism, when our interpretations of behavior recognize that events currently inaccessible to others, but nonetheless from the behavioral dimension, can influence behavior. |
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Transforming High Poverty Neighborhoods: First Steps From the Behavioral Sciences |
Monday, May 30, 2011 |
11:00 AM–11:50 AM |
607 (Convention Center) |
Area: CSE; Domain: Service Delivery |
CE Instructor: Anthony Biglan, Ph.D. |
Chair: Patricia Bach (Illinois Institute of Technology) |
ANTHONY BIGLAN (Oregon Research Institute) |
Anthony Biglan, Ph.D. is a Senior Scientist at Oregon Research Institute and the Co-Director of the Promise Neighborhood Research Consortium. He has been conducting research on the development and prevention of child and adolescent problem behavior for the past 30 years. His work has included studies of the risk and protective factors associated with tobacco, alcohol, and other drug use; high-risk sexual behavior; and antisocial behavior. He has conducted numerous experimental evaluations of interventions to prevent tobacco use both through school-based programs and community-wide interventions. He has also performed evaluations of interventions to prevent high-risk sexual behavior, antisocial behavior, and reading failure. He and colleagues at the Center for Advanced Study in the Behavioral Sciences published a book summarizing the epidemiology, cost, etiology, prevention, and treatment of youth with multiple problems (Biglan et al., 2004). He is a former president of the Society for Prevention Research. He was a member of the Institute of Medicine Committee on Prevention, which recently released its report documenting numerous evidence-based preventive intervention. |
Abstract: Prevention science has arrived at the point where it is realistic to experimentally evaluate comprehensive interventions to improve child and adolescent development in high poverty neighborhoods. This presentation will review the evidence in support of this statement. Numerous family and school interventions that have been shown to prevent multiple problems and to enhance the development of prosocial behavior are available. I will then describe one such comprehensive intervention that has been developed on the basis of this evidence. It includes evidence-based programs, policies, and evidence-based kernels. I will then lay out the multiple baseline experimental design that is proposed for evaluating it. In addition, I will describe work we have been doing on the use of acceptance and commitment therapy to help organizations with issues of stress, social cohesion, and organizational flexibility. |
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Applied Behavior Analysis and the Developmental, Individual Difference, Relationship-Based (DIR/Floortime) Model: Compatible or Incompatible? |
Monday, May 30, 2011 |
11:00 AM–11:50 AM |
Korbel Ballroom 2A (Convention Center) |
Domain: Experimental Analysis |
CE Instructor: Robert Ross, Ph.D. |
Chair: Michael F. Dorsey (Endicott College) |
ROBERT K. ROSS (BEACON Services) |
Dr. Ross is the Senior Vice President of Curriculum and Research at Behavioral Education Assessment and Consultation Inc. (BEACON Services). BEACON Services provides intensive behavioral educational services to children diagnosed with PDD/Autism and behavioral and learning challenges. BEACON Services works in both early intervention and school age programs. He received his Doctorate in Educational Leadership at NOVA Southeastern University and his Masters degree in Applied Behavior Analysis from Northeastern University and is a nationally Board Certified Behavior Analyst (BCBA-D). Dr. Ross is a primary instructor in the BCBA certification programs at Cambridge College in Cambridge Massachusetts and The University of Massachusetts at Dartmouth for BEACON Services. In addition to his teaching and research responsibilities Dr. Ross works directly with individuals with Autism and Aspergers Syndrome as part of his active caseload responsibilities. Dr. Ross serves as a consultant to the Judge-Baker Manville School at Boston Children's Hospital. This school serves children with a range of emotional and behavioral challenges, and his focus is on developing behavioral and instructional interventions for children with Aspergers Syndrome. He also consults to the Perkins school for the Blind's program for children with severe behavioral and learning challenges. Prior to his tenure at BEACON Services Dr. Ross held the position of Behavior Analyst at the Evergreen Center School in Milford, MA. He has worked for the Massachusetts Department of Mental Retardation as a Psychologist and in a similar capacity for a private non-profit program for adults with disabilities. Dr. Ross also serves as the Chair of a Professional Review Committee as part of the State of Rhode Islands Division of Developmental Disabilities oversight of services to individuals with disabilities. He is also a member of the Human Rights Committee for the Evergreen Center Adult Supports program. BEACON Services is active in pursuing cutting edge research in the treatment of children with Autism Spectrum Disorders and Dr. Ross oversees all research activities at BEACON Services. BEACON is currently focusing research efforts in such areas as early literacy, social and play skills, and application of visually supported instructional methods. Dr. Ross has presented on these and other topics at regional, national and international conferences. |
Abstract: Behavior analysts providing early intensive behavioral intervention (EIBI) to children diagnosed with autism spectrum disorders (ASD) may be asked to provide other interventions or collaborate with those providing other services. A large number of supplemental and or competing therapies exist, some of which have empirical support while many others do not. This workshop is designed to comprehensively review the philosophical underpinning, assessment methods, instructional goals and specific instructional practices involved in the implementation of EIBI and the developmental, individual difference, relationship-based (DIR/Floortime) model. This review suggests that a number of specific practices of DIR/Floortime are in direct contradiction to and may undermine the effectiveness of behavior analytically based interventions used in EIBI services. Video exemplars will be use to illustrate these differences. The ethical issues associated with combining these two approaches will also be discussed. |
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Increasing the Probability of Students Engaging in Assigned Work: The Additive Interspersal Procedure and the Discrete Task Completion Hypothesis |
Monday, May 30, 2011 |
2:30 PM–3:20 PM |
Korbel Ballroom 2A (Convention Center) |
Area: EDC; Domain: Applied Behavior Analysis |
CE Instructor: Christopher Skinner, Ph.D. |
Chair: Jennifer L. Austin (University of Glamorgan) |
CHRISTOPHER SKINNER (University of Tennessee) |
Christopher Skinner graduate from Lehigh University with a Ph.D. in school psychology in 1989. He became associate professor in 1993 and Full Professor in 1995 and served as coordinator of School Psychology programs since 1993 (including Mississippi State). His programs have been reviewed and accredited by APA, NASP, State Departments of Education, and NCATE. Skinner has a passion for behavioral theory and practice. Since graduation he has have made over 200 peer-reviewed presentations and published over 150 peer-refereed journal articles. Many of these papers have described IN VIVO applied remediation studies (i.e., experiments, often using single-subject designs) where Skinner and his students applied behavioral theory, research methods, problem solving strategies, and interventions. However Skinner has also advanced the field with innovative conceptual and theoretical work including randomly selecting contingency components, precisely measuring learning rates, tootling, the additive interspersal procedures, and the discrete task completion hypothesis. |
Abstract: Within classroom settings, students can choose to engage in desired behavior or a host of competing alternative behaviors. Enhancing relative rates of reinforcement can increase the probability of students choosing to engage in assigned work. In this presentation, I will review research on variables that affect choice. I also will describe and analyze research on the discrete task completion hypothesis (when given an assignment comprised of many discrete tasks, each complete task is a reinforcer) and the additive interspersal procedure, which show how educators can arrange contingencies such that students choose assignments requiring more effort (e.g., 20% more long math problems) by adding even more work (some additional shorter problem). Those who attend will acquire an understanding of how the classroom (and life) is essentially a continuous choice paradigm and how those choices affect learning. In addition, attendees will learn a counterintuitive procedure designed to enhance the probability of students choosing to do higher effort work. Finally, I hope to expand attendees' basic understanding of reinforcers and describe how learning histories, along with rate, quality, and immediacy of conditioned reinforcement, can interact with effort to influence choice classroom. |
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Neurotransmitter Interactions Involved in Selection of Instrumental Responses and Effort-Related Choice Behavior |
Monday, May 30, 2011 |
2:30 PM–3:20 PM |
401/402 (Convention Center) |
Area: SCI; Domain: Experimental Analysis |
CE Instructor: John Salamone, Ph.D. |
Chair: Karen G. Anderson (West Virginia University) |
JOHN SALAMONE (University of Connecticut) |
I received my undergraduate degree in Psychology in 1978 (Rockurst College), and my Ph.D. in Psychobiology from Emory University in 1982 (Advisor: Darryl Neill). I received a NSF postdoctoral fellowship to work with Susan Iversen at the Experimental Psychology Laboratory at Cambridge University in England (1982-1983). After a few years of working in the pharmaceutical industry (Merck, 1984-1986), I was a research fellow at the University of Pittsburgh, where I worked with Michael Zigmond and Edward Stricker. I joined the Psychology and Neuroscience faculty at the University of Connecticut in 1988, and I am now a Board of Trustees Distinguished Professor, in the Psychology department. I am head of the behavioral neuroscience division, and chair of the Program in Neuroscience. |
Abstract: There are numerous problems with the traditional view that brain dopamine (DA) systems, particularly in the nucleus accumbens, directly mediate the "rewarding" or primary motivational characteristics of natural stimuli such as food. The present review is focused upon the involvement of nucleus accumbens DA in the selection of instrumental responses based upon effort-related processes. Viewed from the framework of behavioral economics, the effects of accumbens DA depletions and antagonism on food-reinforced behavior are highly dependent upon the work requirements of the instrumental task, and DA depleted rats show altered elasticity of demand for food. Moreover, interference with accumbens DA transmission exerts a powerful influence over effort-related choice behavior. Rats with accumbens DA depletions or antagonism reallocate their instrumental behavior away from food-reinforced tasks that have high response requirements, and instead these rats select a less-effortful type of food-seeking behavior. Nucleus accumbens DA and adenosine interact in the regulation of effort-related functions, and other brain structures (anterior cingulate cortex, amygdala, ventral pallidum) also are involved. Studies of the brain systems regulating effort-based processes may have implications for understanding drug abuse, as well as energy-related disorders such as psychomotor slowing, fatigue or anergia in depression and other disorders. |
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Can Drugs Help Us Understand Cognitive and Executive Functions? |
Monday, May 30, 2011 |
3:30 PM–4:50 PM |
401/402 (Convention Center) |
Area: SCI; Domain: Experimental Analysis |
Chair: Paul L. Soto (Johns Hopkins University) |
CE Instructor: Paul Soto, Ph.D. |
Abstract: Deficits in cognitive and executive functioning occur with aging and exposure to toxicants and are common across a number of neurological diseases such as Alzheimer's and Parkinson's disease. The neurobiological systems involved in the behavioral processes commonly referred to as memory, executive function, and impulsivity are the subject of intensive research both from a basic science standpoint and for those interested in the development of pharmacotherapeutics. Pharmacological analyses may provide clues regarding the neurobiological systems involved in these processes and are necessary for the development of pharmacotherapeutics. The following symposium will highlight studies on the effects of drugs on behavioral processes referred to as memory, executive function, and impulsivity. Chris Newland will present data on the effects of calcium channel blockers in an incremental repeated acquisition procedure. Suzanne Mitchell will present data on the effects of dopamine D2 receptor antagonists in a variety of discounting procedures. Mark Galizio will present data on putative cognitive enhances in titrating delayed-matching-to-sample (DMTS) and memory span procedures. Paul Soto will present data on alpha5-selective GABAA inverse agonists in a DMTS procedure. These studies will highlight the involvement of multiple neurotransmitter systems in cognitive and executive functions and interactions between those systems and behavioral variables. |
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Incrementing Non-Match-to-Sample: Drug Effects in an Animal Memory Span Task |
MARK GALIZIO (University of North Carolina, Wilmington) |
Abstract: The olfactory span task is a non-match to sample procedure developed in rodents in which the number of stimuli controlling responding increments after each trial. Accuracy decreases as the number of stimuli to remember increases which provides some validation for the task. I will present data collected from a novel adaptation of this procedure will show the effects of several drugs including some putative memory enhancers (e.g., olanzapine, xanomeline) and others which are posited to interfere with remembering (e.g., MK801/dizocilpine, chlordiazepoxide, scopolamine). In general, the procedure is quite sensitive to drugs that interfere with accuracy, but perhaps surprisingly, ceiling effects may limit the use of the procedure with enhancers. A representive figure showing the effects of dizocilpine is attached. |
Dr. Galizio received his BA from Kent State University and his PhD from the University of Wisconsin- Milwaukee where he worked with Dr. Alan Baron. In 1976, he joined the faculty at the University of North Carolina Wilmington where he is currently Chair and Professor of Psychology. His research interests include behavioral pharmacology, stimulus control/concept learning, aversive control, and human operant behavior. He has published two books and more than 70 articles and his research has been supported by NIDA, NSF and NICHD. He is a Fellow of four APA divisions and is a past-president of APA Division 25 (Behavior Analysis) and of the Southeastern Association for Behavior Analysis. He has served as Associate Editor of JEAB and as a member of the JEAB editorial board for over 18 years. |
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The Value of Work: Role of Dopamine in Effort Discounting |
SUZANNE H. MITCHELL (Oregon Health & Science University) |
Abstract: Studies manipulating the effort required to earn a reinforcer often alter the number of responses required to earn rewards, establishing a correlation between the effort required and the time taken to earn the reinforcer. This makes it difficult to disambiguate the mechanisms involved in assessing effort-associated costs from those involved in assessing temporal costs. To examine this, the subjective value of a sucrose reward that was delayed or required a single large effortful response was measured in rats. Delay discounting increased following raclopride (a D2R antagonist; Exp1) but not SCH-23390 (a D1R antagonist; Exp2). Effort discounting was unaffected. In a follow-up study, the requirements for the delay and effort groups were derived from the performance of subjects required to complete different numbers of responses to earn the reinforcer (Response Group). Early data with raclopride administration suggest that D2 receptors only have a role in effort discounting if the effort requires multiple responses over time. |
Suzanne H. Mitchell, Ph.D., is an Associate Professor at Oregon Health & Science University (OHSU) in the Behavioral Neuroscience and Psychiatry departments. She obtained her undergraduate degree at the University of Hull, England and her Ph.D. at SUNY-Stony Brook. Her thesis examined the economics of foraging behavior of rats, examining the role of the energetic costs and benefits in feeding. Her committee was chaired by Howard Rachlin, whose influence made her sensitive to the role of temporal costs as well as energetic costs in determining the value of food rewards. During a post-doctoral fellowship at the University of Chicago, Dr. Mitchell worked with Harriet de Wit focusing on using behavioral economics as an explanation for use of alcohol, cigarettes, and amphetamine in humans. During that time she also began collaborating with Jerry Richards on delay discounting studies with rats. Dr. Mitchell moved her lab to OHSU in 2001 from the University of New Hampshire to devote more time to research, particularly looking into why drug users tend to be more impulsive than non-drug users using human and animal models. |
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Differential Effects on Learning by Four Calcium Channel Antagonists |
JORDAN M. BAILEY (Auburn University), M. Christopher Newland (Auburn University) |
Abstract: Calcium regulation has long been implicated in learning processes and compounds that affect this regulation may have detrimental consequences to normal functioning. Most studies have used drugs that act on ligand-gated calcium channels to investigate this issue. Here we emphasize L-type calcium-channel blockers (CCBs), which act on voltage-gated channels and are used clinically for the treatment of cerebral ischemia and hypertension. Nifedipine, verapamil, and nimodipine were administered to mice performing an incremental repeated acquisition (IRA) procedure. This procedure requires the acquisition of a different response chain, repeatedly. A control procedure requires the performance of a particular chain. Ketamine, which antagonizes ligand-gated NMDA receptors on Ca++ channels, was also used. For all four drugs a range of doses was injected ip to BALB/c mice (N=8). Responding decrements and learning/performance deficits were seen with nimodipine (3 mg/kg). Verapamil did not produce any behavioral effects. Nifedipine reduced responding (3 mg/kg), but no changes in learning or performance occurred. Ketamine selectively impaired learning (3 mg/kg and higher). The drug that acts on ligand-gated Ca++ channels disrupted learning selectively but none of the drugs that block voltage-gated channels did so. Although the CCBs have similar mechanisms of action, they differ from each other in their behavioral effects and differ as a group from ketamine. |
Jordan Bailey earned her B.A. in Psychology from Auburn University in 2006 and M.S. in Experimental Psychology form Auburn University in 2009. Her master’s thesis assessed the effects of low-dose d-amphetamine administration on learning and since then she has completed numerous drug challenges to behavior during acquisition-tasks. She is currently completing her doctoral work in which she is investigating the effects of neurotoxicant (MeHg) exposure on learning as well as various pharmacological agents that may attenuate the effects of neurotoxicant exposure. Chris Newland is an Alumni Professor at Auburn University. His research interests include the applications of behavior analysis and behavioral pharmacology to an understanding of the actions of neurotoxic substances, especially heavy metals. This has led to an interest in how early developmental, even fetal, neural damage can result in long-term disability and early onset of aging. His research is supported by the National Institute of Environmental Health Sciences.
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The Selective a5GABAA Inverse Agonist RY-23 Enhances Delayed-Match-to-Sample Performance and Antagonizes Triazolam's Effects in Rhesus Monkeys |
PAUL L. SOTO (Johns Hopkins University), Sundari Rallapalli (Johns Hopkins University), James E. Cook (Johns Hopkins University), Nancy A. Ator (Johns Hopkins University), Michael Weed (Johns Hopkins University) |
Abstract: It has been suggested that inverse agonists at the benzodiazepine (Bz) binding site on a5GABAA receptors (a5GABAARs) might serve as potential therapeutics for Alzheimer's disease-associated memory loss. The present study evaluated the effects of RY-23, a selective a5GABAAR inverse agonist, in rhesus monkeys responding on a delayed-matching-to-sample (DMTS) or spatial working memory (SWM) procedure. DMTS trials began with presentation of a photo image (sample) on a touchscreen. Touching the image initiated a delay followed by presentation of three images, one matching the sample. Touching the matching image produced a food pellet. Touching either of the other images produced a timeout. SWM trials began with presentation of a configuration of boxes. Each non-repeat touch produced a food pellet, whereas repeat touches produced a timeout. Accuracy decreased with increased delay (DMTS) or box number (SWM). RY-23 produced a modest increase in DMTS, but not SWM accuracy. RY-23 dose-dependently antagonized the effects of triazolam in the DMTS and SWM procedures, but did so less effectively in the SWM procedure. The results suggest a greater involvement of a5GABAARs in the memory-impairing effects of triazolam on DMTS performance and further suggest the importance of a5GABAARs as a potential therapeutic target for memory loss. |
Paul L. Soto, Ph.D., is an Instructor in the Department of Psychiatry at Johns Hopkins University (JHU). He obtained his undergraduate degree from the University of Florida and his Ph.D. from Emory University. He completed a postdoctoral fellowship at the National Institute on Drug Abuse Intramural Research Program and then joined the faculty at JHU in 2008. His research interests include behavioral pharmacology with specific interests in the evaluation of potential pharmacotherapeutics for drug abuse and deficits associated with neurological diseases such as Alzheimer’s disease. |
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